Find out more about the symptoms, diagnosis and treatment of this type of non-Hodgkin lymphoma.
Update Date: 17.06.2025
Burkitt lymphoma is a type of lymphoma. Lymphoma is cancer that affects the lymphatic system. The lymphatic system is made up of organs, glands, tubelike vessels and clusters of cells called lymph nodes. It's part of the body's germ-fighting immune system.
There are many types of lymphoma. Lymphoma types are often divided into two categories: Hodgkin lymphoma and non-Hodgkin lymphoma. Burkitt lymphoma is a type of non-Hodgkin lymphoma.
Burkitt lymphoma starts in a type of germ-fighting white blood cell called B cells, also called B lymphocytes. In Burkitt lymphoma, changes happen that turn the B lymphocytes into cancer cells. The cancer cells can grow in the lymph nodes, jaw or other bones in the face, parts of the intestines, bone marrow, central nervous system, and other areas of the body.
Burkitt lymphoma is an aggressive type of cancer, but it may be cured when diagnosed and treated right away. Treatment for Burkitt lymphoma often includes a combination of chemotherapy medicines. Other treatments may include immunotherapy, clinical trials, bone marrow transplant, also called a bone marrow stem cell transplant, and radiation therapy.
The types of Burkitt lymphoma include:
The term "Burkitt leukemia" may be used to describe Burkitt lymphoma that is found in the blood and bone marrow.
Burkitt lymphoma signs and symptoms may include:
Burkitt lymphoma can happen in the part of the belly where the large intestine and small intestine meet. This is known as the ileocecal region. When this region is affected, symptoms may include:
If Burkitt lymphoma is present in the brain and spinal cord, it may cause neurological symptoms such as headaches, confusion, vision changes and more.
Make an appointment with a doctor or other healthcare professional if you have any symptoms that worry you.
It's not clear what causes Burkitt lymphoma. This cancer starts in a type of white blood cell that fights infections, called a B cell, also known as a B lymphocyte. In Burkitt lymphoma, gene changes cause the cell's DNA to rearrange. This is known as translocation. Translocation causes the B lymphocytes to turn into cancer cells. The cancer cells can build up in different areas of the body and cause tumors.
Factors that can increase the risk of Burkitt lymphoma include:
A complication of Burkitt lymphoma is the risk of the cancer coming back. Even after successful treatment, Burkitt lymphoma may come back. This is called a relapse. The risk of relapse is higher in people with cancer of the central nervous system. For people who have relapsed, the prognosis is much worse.
Burkitt lymphoma diagnosis often begins with a physical exam that checks for swollen lymph nodes and a neurological exam, which tests how well the brain and nerves are working. Other tests and procedures might include blood tests, imaging tests and taking a sample of tissue for lab testing.
Blood tests can sometimes show whether lymphoma cells are present. Blood tests also measure levels of lactate dehydrogenase (LDH). This enzyme is often higher in people with lymphoma. Blood tests also can check for infections that may increase the risk of Burkitt lymphoma, such as Epstein-Barr virus and HIV.
Imaging tests make pictures of the body. They can show the location and extent of Burkitt lymphoma. Tests might include CT and positron emission tomography (PET) scans. Your healthcare team also may do an MRI if they think the cancer is affecting the central nervous system.
Your healthcare professional may suggest a lymph node biopsy to look for cancer cells. A biopsy is a procedure to remove a sample of tissue for testing in a lab. A lymph node biopsy involves removing all or part of a lymph node. In the lab, tests may show whether you have Burkitt lymphoma.
Bone marrow aspiration and biopsy are procedures to collect cells from the bone marrow for testing. Bone marrow is the soft matter inside bones where blood cells are made. Bone marrow has a solid part and a liquid part.
In a bone marrow aspiration, a needle is used to draw a sample of the fluid. In a bone marrow biopsy, a needle is used to collect a small amount of the solid tissue. The samples are typically taken from the hip bone. The samples go to a lab for testing. In Burkitt lymphoma, this procedure is done to help determine the cancer's extent.
A lumbar puncture is a procedure to collect fluid from around the spinal cord. A lumbar puncture, also called a spinal tap, is done using a needle. A healthcare professional inserts the needle between two bones in the lower back and draws out some of the fluid that surrounds the brain and spinal cord. This fluid is called cerebrospinal fluid. The fluid goes to a lab where it's tested for cancer cells.
For Burkitt lymphoma, a lumbar puncture may be done if you have any neurological symptoms. It also may be done if you are at higher risk of lymphoma of the central nervous system.
Lymphoma cells collected from a lymph node biopsy or bone marrow aspiration and biopsy go to a lab for testing. In the lab, specialized tests look for specific things about the cells. The healthcare team uses the results to decide on the type of lymphoma that you have.
To decide whether the cells are Burkitt lymphoma cells, the healthcare professionals in the lab look for:
If you're diagnosed with Burkitt lymphoma, the next step is to determine the extent of the cancer, called the stage. Imaging tests, blood tests and biopsies may be used to determine the stage of your Burkitt lymphoma. Your healthcare team uses the cancer stage to help create your treatment plan.
The stages of Burkitt lymphoma range from 1 to 4:
The cancer prognosis tells you how likely it is that the cancer can be controlled. Your healthcare team can get a general sense of your outlook using your Burkitt lymphoma stage. But the stage can't tell your future. Your personal prognosis may depend on:
Talk with your healthcare team about your prognosis if you want to know what to expect. Your healthcare team can explain what is considered when thinking about your prognosis.
Burkitt lymphoma survival rates depend on several factors, including the stage, what treatments are used and if the central nervous system is involved. In children, survival rates are often above 90% when treated right away. This is especially true in children with stage 1 or stage 2 cancer that hasn't spread. In adults, the survival rates range from 50% to 90% depending on overall health.
Burkitt lymphoma is typically treated with a combination of chemotherapy medicines. Burkitt lymphoma may be cured if treated right away. Other treatments may include chemotherapy, immunotherapy, clinical trials, bone marrow transplant, also called stem cell transplant, and radiation therapy. Which treatment is best for you depends on the extent of your cancer, called the stage. Your healthcare team also considers how quickly the cancer is growing, your overall health and what you prefer.
Chemotherapy treats cancer with strong medicines. There are many chemotherapy medicines. Most chemotherapy medicines are given through a vein. Some come in pill form.
Chemotherapy is often the first treatment used for Burkitt lymphoma. Several chemotherapy medicines may be used at once. Chemotherapy may be combined with immunotherapy. Other medicines may be used at the same time to protect the central nervous system. Chemotherapy also may be used in people whose cancer has come back after treatment, called relapsed Burkitt lymphoma. In people with HIV, medicines called antiretrovirals may be given during or after chemotherapy treatment.
Immunotherapy for cancer is a treatment with medicine that helps the body's immune system kill cancer cells. The immune system fights off diseases by attacking germs and other cells that shouldn't be in the body. Cancer cells survive by hiding from the immune system. Immunotherapy helps the immune system cells find and kill the cancer cells.
Immunotherapy may be used as a first line treatment for Burkitt lymphoma. It is often combined with chemotherapy. Immunotherapy also may be combined with other medicines in people with advanced cancer or cancer that has come back after treatment, known as relapsed Burkitt lymphoma.
Clinical trials are studies of new treatments. These studies provide a chance to try the latest treatments. The risk of side effects might not be known. Ask your healthcare team if you might be able to be in a clinical trial.
Clinical trials are often used to treat Burkitt lymphoma that has come back after treatment, known as relapsed Burkitt lymphoma. They also may be used to treat Burkitt lymphoma that hasn't responded to other treatments, known as refractory Burkitt lymphoma.
A bone marrow transplant, also called a bone marrow stem cell transplant, involves putting healthy bone marrow stem cells into the body. These cells replace cells hurt by chemotherapy and other treatments.
Stem cells can come from your own body, called an autologous transplant, or from a donor, called an allogeneic transplant. A stem cell transplant may be an option for some people whose cancer has returned after a long period of remission.
Radiation therapy treats cancer with powerful energy beams. The energy can come from X-rays, protons or other sources. During radiation therapy, you lie on a table while a machine moves around you. The machine directs radiation to precise points on your body.
Radiation therapy may be used for advanced Burkitt lymphoma to relieve symptoms and improve quality of life. This is known as palliative radiation therapy.
After treatment is complete, you may have frequent follow-up appointments to see if the cancer has come back, known as a relapse. For Burkitt lymphoma, most relapses happen in the first year after treatment. You may have repeat blood and imaging tests and, if needed, biopsies, to check for relapse.
Treatments for Burkitt lymphoma may have side effects. These may include nausea, vomiting, fatigue, fever, rash, diarrhea and more. Harmful side effects from treatments may include:
With time, you'll find what helps you cope with the uncertainty and worry of a cancer diagnosis. Until then, you may find it helps to:
Ask your healthcare team about your cancer, including your test results, treatment options and, if you want, your prognosis. As you learn more about Burkitt lymphoma, you may become more confident in making treatment decisions.
Keeping your close relationships strong can help you deal with Burkitt lymphoma. Friends and family can provide the practical support you may need, such as helping take care of your home if you're in the hospital. And they can serve as emotional support when you feel overwhelmed by having cancer.
Find someone who is willing to listen to you talk about your hopes and worries. This may be a friend or family member. The concern and understanding of a counselor, medical social worker, clergy member or cancer support group also may be helpful.
Ask your healthcare team about support groups in your area. Other sources of information include the National Cancer Institute, the American Cancer Society, the Leukemia & Lymphoma Society and the Lymphoma Research Foundation.
Make an appointment with a doctor or other healthcare professional if you have any symptoms that worry you.
If your healthcare professional thinks you might have Burkitt lymphoma, you may be referred to a doctor who specializes in diseases that affect blood cells, called a hematologist. If a cancer diagnosis is made, you also may be referred to a doctor who specializes in treating cancer, called an oncologist.
Because appointments can be brief, it's a good idea to be prepared. Here's some information to help you get ready.
Your time with your healthcare team is limited, so preparing a list of questions can help you make the most of your time together. List your questions from most important to least important in case time runs out. For Burkitt lymphoma, some basic questions to ask include:
Don't hesitate to ask other questions.
Be prepared to answer questions, such as:
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